Currently there is no option to bulk disable/delete users. If you have an external user directory you can remove that directory which will effectively remove the users from your instance.
You can also take a look at the Communities post Solved: How do you bulk delete or deactivate users? One recommendation is an addon called User Deactivator for JIRA.
One of our Partner Champions Bob Swift also stated the CLI add-on can perform bulk operations of this sort.
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