Nothing that I would consider anything more than "very mildly inconvenient"
- Licence renewals will take a couple of extra clicks if starting from Jira
- Install of apps will take many more clicks
- The only major one: you won't get told about available updates to apps or applications, you'll need to keep an eye on them on via checking manually on a client machine that can see the internet
Security often trumps that. If you do have a non-internet Atlassian system, it will work fine, but the admins do need to keep on top of releases by checking regularly. (The most secure place I know has internet connected servers dedicated to checking for updates and release notes, so they can tell humans when something behind the firewall might need updates)
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