is it possible to create tickets or issue with sending mail?

[yawo manasse]

user will send mail, and issue will be automatically created by using the email.

[darylchuah]

For more advanced settings, perhaps you might want to use this JEMH (JIRA Enterprise Mail Handler) plugin which provide extensive feature on customization for mail handler in JIRA.

[Zul NS [Atlassian]]

Yes, this is possible in JIRA by configuring Mail Handler