JIRA & Confluence slow behind Pound reverse proxy

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I'm running Pound for URL based redirects (i.e. redirect jira.mydomain.com to 10.10.10.1:8080) and I'm having issues that both JIRA and Confluence are intermittently very slow.

During the same periods, this is what I see in the pound logs:

Jul 17 12:32:13 fw1-vm1-wdcsl pound: (b7222b70) error read from x.x.x.x: Connection timed out

Jul 17 12:32:13 fw1-vm1-wdcsl pound: (b7084b70) error read from x.x.x.x: Connection timed out

Jul 17 12:32:13 fw1-vm1-wdcsl pound: (b7044b70) error read from x.x.x.x: Connection timed out

Jul 17 12:32:55 fw1-vm1-wdcsl pound: x.x.x.x GET / HTTP/1.1 - HTTP/1.1 302 Moved Temporarily

Jul 17 12:33:00 fw1-vm1-wdcsl pound: x.x.x.x GET /homepage.action HTTP/1.1 - HTTP/1.1 302 Moved Temporarily

Jul 17 12:33:00 fw1-vm1-wdcsl pound: x.x.x.x GET /dashboard.action HTTP/1.1 - HTTP/1.1 200 OK

Jul 17 12:33:00 fw1-vm1-wdcsl pound: x.x.x.x GET /rest/menu/latest/appswitcher?_=1374078837002 HTTP/1.1 - HTTP/1.1 200 OK

If I'm using jira directly from the server, connecting to localhost, everything is fairly snappy.

Are there specific settings I need to make to get this to work properly with pound?

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I've now replaced Pound with nginx and since, everything works perfectly