Simplify and housekeep - there's a lot of performance tuning tips out there, but the main things you can do is avoid fielditis (limit the custom fields, resisting "we need a new field" requests, share them as much as possible, and limit their context), share workflows and other configuration, clean out what you're not using. Archive where possible. Use roles instead of groups for permission schemes, remove any config you are not using, and try to merge as much as possible
Upgrade to 8.5 - the update to the Lucene index in 8.0 alone is a huge improvement
Move to Data Centre so you can balance and optimise load
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