Is it possible to have a column that sends a notification to selected users when a card is dropped into that column? Then, when the card is moved to the next column, it does not send any new notifications.
A column is one or more status grouped together. So, when you drag from one column to another, JIRA is, in the background, moving issues through your workflow. Workflow transitions fire "events", which are picked up by the "notification scheme" in order to send email when things happen.
So, the answer is "yes", but you need to understand the workflow.
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