Yes it's possible. For every workflow transition there is a "Generic Event" which is Triggered everytime, it's the default event for workflow. Now, you can create your own event "No Notification", in the post-function of the transition leading to the workflow step edit the Event name and replace Generic Event by "No Notification" event. And in your notification scheme of the project make sure the event "No Notification" is not sending any mails to anyone.
I have multiple projects that use variations of the same base workflow. The variations depend on the requirements of the project or issue type. The variations mostly come in the form of new statuses ...
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