Is it possible, that once a ticket has been moved to in progress and assigned you can not change clear the assignee. You can change it to someone else, but it can never be empty while in progress. Is that possible? Maybe if empty goes back to backlog.
Joe's disallow unassigned issues is the easiest and probably best answer, but you could also
By clearing, I presume you mean setting it to unassigned. You need to setup JIRA not to allow unassigned issues and that will solve the problem. From my experience unassigned issues aren't worked because they don't appear in the assigned to me display.
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