It's not possible to do this without an plugin.
If you have the paid plugin Script runner installed then you can easily do it.
issuetype = Epic and issueFunction not in hasLinkType("Epic-Story Link")
the above JQL will give you all epics in the system which don't have a child story.
I have multiple projects that use variations of the same base workflow. The variations depend on the requirements of the project or issue type. The variations mostly come in the form of new statuses ...
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