Hi Praveen,
Atlassian have published guidance on this and is available at https://confluence.atlassian.com/adminjiraserver073/jira-applications-installation-requirements-861253014.html#JIRAapplicationsinstallationrequirements-Server-siderequirementsforproduction
Based on your expected metrics above - you should fit in the below:
However, there are numerous other considerations for right-sizing your infrastructure such as custom fields, number of workflows, scripting, how many requests those 50 concurrent users create, and the number and type of apps (add-ons/plugins) you install, so whatever you start with, monitor closely to start and adjust up or down to suit, and then continue to monitor as usage grows.
CCM
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