Is anyone out there using JIRA to run a combination of projects, BAU process and ad-hoc requests?

[Simon Cowling]

My dream is to have one system to manage workload. 

Currently, we are using a combination of tools (Asana, Trello, JIRA, GSheets, email and others) to run and manage our workload and activities, which is a mixture of big chunky programs, tactical projects, BAU processes (monthly / weekly frequency) and ad-hoc sporadic requests for updates / support. 

Interested if anyone out there is running a similar set of activities all on JIRA, and how they might have configured it? 

Best,

Simon.