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If you're asking as an internal admin then you could query the actions API to figure out who has installed Power-Ups on boards. Also if you know the boards on which the Power-Ups are installed then you could look at the members on the board, right?
If you're after a list of all Trello users (including those inside and outside of your workspace/company) who use any Power-Up - then you will never be able to get that data since that will only be internal to Trello/Atlassian for obvious security and privacy reasons.