Remove the users "create issue" permission.
Your process that uses the API will need to run as a dummy user who still has the permission though.
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Can i define this permission project related?
If yes then how?
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I'm not going to re-type the documentation - see https://confluence.atlassian.com/display/JIRA/Managing+Project+Permissionshave a go at it and let us know if you get stuck. (I'd recommend copying the existing scheme and modifying the copy, that way, if you go wrong, you can swap the project back to the old scheme)
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