I would advise against building your automation strategy using external tools.
Calling the REST api can be an option if a lot of your process and data exists in other systems. The REST API framework is really more for building integrations between systems.
Generally, Jira automation needs to be triggered by and act on internal parts of the Jira system.
I would start with the no-code option where possible using Project Automation.
If you decide you need more control and plan on embarking on building some relevant coding experience, I would direct you towards groovy/java based tool over python ones.
The python-based scripting tools might be a good alternative for someone trying to bring existing Python skills to the Atlassian ecosystem, but since the application is written in Java, using a Java-based scripting language like Groovy makes a lot more sense.
My recommendation is to explore project automation first then Adaptavist Scriptrunner second.
And only use REST API if you need to trigger changes in Jira based on events taking place in other external systems.
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