Hi Jilong Sun,
If you intend to use MySQL as your database server, then you will absolutely need to make sure that you meet all the requirements at Database Setup for MySQL, including the READ-COMMITTED isolation level. If it doesn't meet these requirements then it won't work properly with Confluence.
I'm not sure what you mean by cloud database, but you will want to talk to your provider and see if you can meet those requirements, or else use a different database type.
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