I need to create 2 unique 'unassigned' queues.
1 that captures all unassigned tickets and a 2nd, that captures all unassigned tickets that meet a summary or description criteria.
For example:
Any ticket that has a summary or description that includes 'VCTSI' within any string of text, needs to be assigned to the 'FDA unassigned' queue.
ex) 
If a ticket does not have 'VTCTSI' that it should go to standard unassigned.
I'm running into an issue here where if I include !~ "VCTSI" in the standard unassigned queue then none of the regular tickets appear here and get lost.
Is it possible to differentiate with such close criteria between the two?
Many 'standard' unassigned cases will include "CTSI" in the description or summary and JQL doesn't seem to be able to differentiate.
ex) Standard unassigned ticket

Any ideas?
Thank you!