It is possible.
You need to define the conditions you want to trigger your notification and do something along the lines of the following (in this example I'll create a notification for a fixed email address that reminds of the due date 48h before it expires)...
If you want to notify to dynamic recipients (only the assignee, project roles, watchers...) I believe your best option is to create a new status in your workflows. Call it "dueDate approaching" or similar. Make it so on transition it sends the email. Then simplyl follow the same steps explained before but instead of sending an email on the 3rd step, just create an automatic transition to that new status.
Hope it helps.
You can achieve this with Butler rules, it wouldn't give you a notification, but it would email you (or another member of the team) and let you know that the card is due. I don't know if that would be useful to you, but I thought that I would suggest it just in case:
For help on what Butler commands will accept (variables), see this site https://help.butlerfortrello.com/article/27-variables
I hope that's helpful, if I can assist in any other way, please let me know!
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