i wanted to set escalation matrix for JSD project issue like ... Issue will created and assign to someone(admin), if responsible person is not responded on that issue within 48hr then the issue goes into 1st level escalation and assigned to manager, if he/she is not responded on that issue within 24hr then the issue will goes to 2nd level escalation and issue will be escalated.
and if he/she respond on that issue within 24hr then the issue escalation will be changes from 2nd level to 1st level escalation.
You could do this basically through Automation. I'd suggest looking into the built-in 'keep on top of SLA's' automation rule, which allows you to take different / multiple actions in a scenario that looks very much like the one you are describing:
Screen Shot 2016-12-27 at 12.16.31.png
You can find the automation rules through Project Settings - Automation. Over there, click 'Add rule' and you should find it the above rule listed.