After changing the Base URL for our installation, we began receiving security ceritifcate errors in client-side apps (eg Visual Studio Connector). The only detailed error message indicated "server certificate is not trusted" for https://<old-servername>/images/genericissue.gif?.... (The old server name still works as an alias for this server, otherwise this would have resulted in "server not found" errors.)
Eventually, after some digging in the database, I found the issuetype table. The ICONURL field for most of the rows is a relative path (/images/icons/____.gif), but five rows contain absolute paths. The DESCRIPTION field on these rows all begin "For Go2Group SYNAPSE...."
I've submitted this to the developer as a bug report.