We are using Confluence version 5.3 and have enabled the Office Connector. We have many users who are having no trouble at all using the Edit Document link to edit an embedded Excel spreadsheet. However, we have a few users who receive the above error every time they try. We have been through all of the security settings in both IE8 and IE9 to no avail, even on the same machine. We are using Office 2010. I have verified the Sharepoint entries are set to Run from My Computer, though none of them seem to be the same as the related articles Google turns up for this. Please help!