Could you specify the condition you would base the deactivation? I believe you may be able to achieve this through SQL (that is, if you are using JIRA Server).
Hello Nanda,
You can query your database for users:
select * from cwd_user
and can simply change the "active" value to 0, instead of 1. This will automatically deactivate the user.
Create a script that will deactivate the users:
1) Through the JIRA API https://docs.atlassian.com/jira/REST/latest/
2) Throught the database https://developer.atlassian.com/jiradev/jira-architecture/database-schema
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