We recently upgraded to Confluence 4.3.3 and have come across one of these problems.
Attached a jpeg/png image to a page in a space.Added the image on the page for display as an image macro.
The image is shown on the page after saving.However if we click on the image for an enlarged view,we get a pop up message "The requested content is not currently available.Please try again later".This behaviour is only seen in IE8 and cannot be replicated in Firefox.
Has anyone come across such an issue and if yes,is there a workaround for this.