This issue has been ongoing for the last week, and was only noticed when one of our technicians mentioned that they had not received any notifications from the service desk. Upon checking the mail queue, it was discovered that the queue was significantly backed up. Manually flushing the queue was successful at resolving the issue temporarily. However, the issue still occurs afterwards.
Version of JIRA Service Desk: 4.2.0
Version of JIRA Core: 8.2.0
No additional plugins.