Hi John,
It is possible to set up this with a Butler rule whereby you can use a trigger of a custom field being set to make a calculation and set another custom field to the result. Here is some information about this: https://help.trello.com/article/1161-custom-field-arithmetic. Alternatively, you could take a look at the Smart Fields Power-up which is offered by a third-party and allows you to make calculations within the fields.
Thanks!
Ryan
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