I dont think there is a bulk delete of users at this moment (not in 4.4.1 at least). but what you can do is bulk-remove them from jira-users group, which disable these users from accessing JIRA. You can do this by Admin -> Groups -> jira-user, and mult-select users that you no longer need.
However, as Marcus had answer on my previous post, you should rename the email address to something else, so that, your deleted users will not get email on tickets that are still assigned to them.
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