To clarify the previous Answers the intermediary version between 2.x.x to 4.3.5 is as describe below:
2.x.x >> 2.7.4 >> 3.5.17 >> 4.3.x
The above intermediary version is necessary to differentiate each major migration in between Confluence release so that it would be easier to troubleshoot if there are any issue occurred during the upgrade process.
Also, please ensure that you backup your instance before any upgrade try so that you have a good checkpoint as a safety precaution.
Hope it helps.
Have a look at the confluence upgrade guide
Please note that you may not achieve a big jump at one go. There is an intermediate upgrade at 3.X.
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