When Firefox 14 was released, the Ctrl-S to submit shortcut stopped working on Jira. However, the shortcut Ctrl-Alt-S still works in Chrome 21. I am using OS 10.7.4.
This is a known issue: https://jira.atlassian.com/browse/JRA-29360
You will have to wait for development to make progress on this. In the meantime, I encourage you to vote and comment on it to help show them that it is important to you.
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