Are you looking to do this within JIRA or outside of JIRA? If it's within JIRA use Script Runner as mentioned. Outside of JIRA you'd need to look at REST API.
Take a look at Jamie Echlin's script runner plugin
https://marketplace.atlassian.com/plugins/com.onresolve.jira.groovy.groovyrunner
Cheers
Bhushan
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What exactly do you want to do?
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