It can be "integrated", but as you say, I've not found anything to help you with it.
The reason it can be integrated is that JIRA provides a REST interface through which other systems can interact with it, so if you're willing to code, you can make the other system talk to it. It's a bit harder the other way, especially on Cloud JIRA where you can't install internal add-ons that could do a lot of the talking, but you might be able to write "Connect" add-ons to handle it.
But, you need to start with a description of what you want from this "integration"?
Not sure why you need DocuSign to integrate with JIRA, but you can integrate with Confluence:
You can then link a JIRA ticket a confluence page if this is the kind of audit trail you need.
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