Not sure about the cloud version but I'll share some thoughts on the server version that may be of help:
What could you do on top of this? You could configure an automation rule so each time the issue is commented (trigger) checks for a JQL (comment ~ XXXXX) and if so you proceed to transition the issue or edit any issue field.
You should be very careful when deciding what keywords are you going to use so the automation is not accidentally trigered with any random reply. That could be more challenging that it initially looks :P
Hope it helps
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