If my JIRA instance may have more 10,000,000 issues.
What is the configuration of hardware need?
How many issues the configuration can support :
CPU: E7-4807 * 4
RAM: 16G * 4
When the JIRA support cluster?
Atlassian have ruled out clustering for the foreseeable future.
You are going to struggle severely with 10 million issues in a single Jira instance, no matter what your hardware. As a guideline, Atlassian were recommending splitting Jira when you approach 200,000 under Jira 3. This has increased a lot since version 3, but I don't believe it's near 10 million.
Atlassian are looking at an archiving setup which would probably help you - I very much doubt you have 10 million *active* issues, and you could probably archive 99% of them. It's not available yet though.
Some Atlassian partners can help you with extremely large Jira installations - you may want to reach out to some of them.
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