After proxy configuration, the following link to Application in Settings->System stopped working.
All other link like Projects, Issues, Add-ons etc works fine.
Can you please assist to solve this problem
I see you opened a support ticket. According to the Support Engineer he directed you to the Community forum: Solved: Installing jira and confluence behind apache on same server and suggest you check your ProxyPass settings and see if setting it to localhost resolves this behavior.
When you're done working with Support please provide the resolution here so the rest of the community can benefit. Also, once you determine the resolution let the Support Engineer on the ticket know the issue is resolved so they can close the ticket.
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