I've created a Plan, using Advanced Roadmaps, but I have something like 650 items showing as not having a parent. Most of these are fine, and I just don't want them to show up on my plan because they haven't been assigned to a Release. How can I exclude items with no Fix Version from my plan?
You can configure the plan to include and exclude whatever issues you want to see.
What I'd recommend is creating a saved and shared Filter that identifies the issues of interest.
In your case, you'd want to exclude issues with no Fix Version, so your Filter should contain some JQL like:
... and fixVersion is EMPTY ...
Once you have that filter, change the configuration of your Plan to be based on that Filter (not on the underlying Project(s)). To do that:
Hopefully you'll like what you see in the Plan.
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