Yes. Set the "jira.issue.editable" property to "false" on the status in the workflows where you want to stop edits.
The default system JIRA workflow does this - if you need a worked example, copy it, edit the copy and look at the properties on the "closed" status.
I have multiple projects that use variations of the same base workflow. The variations depend on the requirements of the project or issue type. The variations mostly come in the form of new statuses ...
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