We all have those little jems that help us get through some annoying task quickly so let's share those with each other! Mine is for the email that piled up over the weekend, make one rapid pass through all the messages and a) discard the cruft, b) flag for immediate response, or c) mark "read later". Then make a second pass and respond to the ones flagged "immediate". This usually gets the urgent stuff knocked out quickly. The goal is 1-min or less on the first pass and 5 min or less on the "immediate" pass.
What's your secret weapon?