I did this for a previous version of Confluence, so, yes, it is possible.
One thing, though is that (as I learned) email is woefully inconsistent, and thus hard to handle flawlessly. Use as much of a pre-packaged mail handler as you have available. (I was using Python, and this was a few years ago -- I don't know if there are better packages available, or if another language might have better facilities.)
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